4-(hexahydro-1H-azepin-1-yl)aniline synthesis
- Product Name:4-(hexahydro-1H-azepin-1-yl)aniline
- CAS Number:57356-18-0
- Molecular formula:C12H18N2
- Molecular Weight:190.28
13663-23-5
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57356-18-0
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$20.00/100mg
Yield:57356-18-0 97%
Reaction Conditions:
with 10% Pd/C;hydrogen in ethanol; under 760.051 Torr; for 24 h;
Steps:
7 Step two: 4-(azepan-1-yl)aniline
To a solution of 7.6 g (34.5 mmol) 1-(4-nitrophenyl)azepane in 100 mL ethanol, 2g (34.5 mmol) 10% palladium on carbon was added. The solution was stirred under 1 atm hydrogen gas for 24 hours. The solution was filtered and concentrated to give 6.4 g of the title compound (97%). 1H NMR (Chloroform-d, 400 MHz) d: 6.67-6.56 (m, 4H); 3.4 (m, 4H); 3.22 (m, 2H); 1.78 (br s, 4H); 1.46-1.68 (m, 4H). MS [M+1]=190.1.
References:
WO2020/252130,2020,A1 Location in patent:Page/Page column 45
111-49-9
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57356-18-0
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350-46-9
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$10.60/1gm:
57356-18-0
24 suppliers
$20.00/100mg