4-Hydroxy-3,5-bis(morpholinomethyl)benzaldehyde synthesis

2synthesis methods

Product Name:4-Hydroxy-3,5-bis(morpholinomethyl)benzaldehyde
CAS Number:1064288-38-5
Molecular formula:C18H26N2O4
Molecular Weight:334.41

110-91-8 Synthesis

110-91-8
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$9.00/1g

50-00-0 Synthesis

50-00-0
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$10.00/25g

99-93-4 Synthesis

99-93-4
833 suppliers
$5.00/25g

4-Hydroxy-3,5-bis(morpholinomethyl)benzaldehyde

1064288-38-5
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Yield:1064288-38-5 100%

Reaction Conditions:

in 1,4-dioxane at 120; for 0.5 h;Microwave irradiation;Green chemistry;regioselective reaction;

Steps:

3.1. General Synthesis of Mannich Bases (2-5)

General procedure: To a solution of 4-hydroxyacetophenone (1) (16 mmol, 2.18 g) and formaldehyde (24 mmol or 32 mmnol) in 1,4-dioxane (15 ml), the corresponding secondary amine (morpholine (2), pyrrolidine (3), peridine (4) or diethylamine (5)) was added using the same ratio of formaldehyde. This mixturewas placed in the MW sealed vessel with stirring. The reaction mixture was irradiated for 15-30 minat 120 °C (power 300 W). TLC was used to monitor the progress of the reaction. After consumptionof the starting materials, the vessel was removed and cooled down to room temperature. The reactionmixture was concentrated under reduced pressure and purified using column chromatography.

References:

Aljohani, Ghadah;Said, Musa A.;Lentz, Dieter;Basar, Norazah;Albar, Arwa;Alraqa, Shaya Y.;Al-Sheikh Ali, Adeeb [Molecules,2019,vol. 24,# 3,art. no. 590]