4-Hydroxy-3-methylpiperidine synthesis
- Product Name:4-Hydroxy-3-methylpiperidine
- CAS Number:33557-57-2
- Molecular formula:C6H13NO
- Molecular Weight:115.17
91600-19-0
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Yield:33557-57-2 99%
Reaction Conditions:
with hydrogen;palladium on carbon in tetrahydrofuran;methanol; under 2585.81 Torr; for 20 h;
Steps:
A.5.3
N-BENZYL-3-METHYLPIPERIDIN-4-OL (5.16 g, 25.13 mmol) was dissolved in 50 mL THF: MeOH 1: 1, with 20% Pd/C (0.5 g) and subjected to 50 psi of hydrogen gas for 20 hours. The crude product was then filtered through celite and then concentrated in vacuo. The crude product was analyzed (2.89 g, 99%) by MS (EI) : m/z 116.0 (M + 1).
References:
WO2005/26145,2005,A2 Location in patent:Page/Page column 103
181269-70-5
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1159982-52-1
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33557-57-2
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181269-69-2
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