ChemicalBook CAS DataBase List 4-HYDROXY-6-METHYLCOUMARIN

4-HYDROXY-6-METHYLCOUMARIN synthesis

14synthesis methods

Product Name:4-HYDROXY-6-METHYLCOUMARIN
CAS Number:13252-83-0
Molecular formula:C10H8O3
Molecular Weight:176.17

106-44-5 Synthesis

106-44-5
464 suppliers
$14.00/5g

141-82-2 Synthesis

141-82-2
740 suppliers
$5.00/25g

13252-83-0
116 suppliers
$18.00/250mg

Yield: 66%

Reaction Conditions:

with zinc(II) chloride;trichlorophosphate at 60 - 65;

Steps:

4 General synthetic procedure for the 4-Hydroxycoumarin derivatives (2a-e)
General procedure: A mixture of phenol (19.8 g, 0.21 mol), anhydrous ZnCl2 (84.8 g, 0.62 mol), POC13 (97 g, 0.63 mol), and malonic acid (22 g, 0.21 mol) was heated at 60-65 °C for 40 h, then the mixture was cooled. After the mixture was decomposed with water, the solid was filtered. The solid was dissolved with 10% aqueous Na2CO3, then acidified with diluted hydrochloric acid. The crystal was filtered to give the product 2a.

References:

Ji, Qinggang;Ge, Zhiqiang;Ge, Zhixing;Chen, Kaizhi;Wu, Hualong;Liu, Xiaofei;Huang, Yanrong;Yuan, Lvjiang;Yang, Xiaolan;Liao, Fei [European Journal of Medicinal Chemistry,2016,vol. 108,p. 166 - 176]