4-HYDROXY-8-METHYLQUINOLINE-3-CARBOXYLIC ACID synthesis

Yield:35966-17-7 50%

Reaction Conditions:

with sodium hydroxide in ethanol; for 5 h;Reflux;Gould-Jacobs Reaction;

Steps:

General procedure for basic hydrolysis

General procedure: A suspension of ester 3e-k (2 mmol) in 4% NaOHhydroalcoholic solution (5 ml) was refluxed until no startingmaterial could be detected by Thin Layer Chromatography(5 h). After cooling, the mixture was completely acidifiedby adding concentrated HCl and the solid obtained wascollected by filtration, washed with water, and crystallizedfrom ethanol to afford compound 4e-k.

References:

Hajimahdi;Zabihollahi;Aghasadeghi;Ashtiani, S. Hosseini;Zarghi [Medicinal Chemistry Research,2016,vol. 25,# 9,p. 1861 - 1876]