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ChemicalBook CAS DataBase List 4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID
83590-77-6

4-HYDROXYMETHYL-3-METHOXYPHENOXYACETIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 8 h / 20 °C / Cooling with ice
3: sodium tetrahydroborate; ethanol / 3 h / 20 °C / Cooling with ice
4: sodium hydroxide; water / ethanol / 4 h / Reflux

References:

East China Normal University;Shanghai Bei Ka Pharmaceutical Co., Ltd.;Luo Yu;Zhou Po;Li Xiaolin;Zhu Haoting;He Yang;Zhang Yuliu;Zhan Li;Wu Wenxuan;Li Qian;Kang Litao;Yang Shiqiong CN107954870, 2018, A

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