4-hydroxyphenylbutazone synthesis

7synthesis methods

Product Name:4-hydroxyphenylbutazone
CAS Number:16860-43-8
Molecular formula:C19H20N2O3
Molecular Weight:324.37

23111-33-3
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16860-43-8
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: acetic anhydride; acetic acid / 24 h / 20 °C / Inert atmosphere
2: N-iodo-succinimide / tetrahydrofuran / 12 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / ethanol / 6 h / 20 °C
4: sodium hydroxide / ethanol; water
5: human placental alkaline phosphatase; magnesium chloride; zinc(II) chloride / 37 °C / pH 7.4 / aq. buffer; Enzymatic reaction
6: dihydrogen peroxide; sodium hydrogencarbonate / water; acetonitrile

References:

Dhareshwar, Sundeep S.;Stella, Valentino J. [Journal of Pharmaceutical Sciences,2010,vol. 99,# 6,p. 2711 - 2723]

50-33-9
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16860-43-8
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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16860-43-8
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References

1000210-73-0
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16860-43-8
18 suppliers
$190.00/y0000147

References

1000210-73-0
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16860-43-8
18 suppliers
$190.00/y0000147

References