4-Iodo-1-[(4-Methoxyphenyl)Methyl]-1H-Pyrazole synthesis
- Product Name:4-Iodo-1-[(4-Methoxyphenyl)Methyl]-1H-Pyrazole
- CAS Number:905751-58-8
- Molecular formula:C11H11IN2O
- Molecular Weight:314.12
824-94-2
444 suppliers
$24.19/5G
905751-58-8
32 suppliers
$60.00/100mg
Yield:905751-58-8 93%
Reaction Conditions:
Stage #1: 4-iodopyrazolewith sodium hydride in N,N-dimethyl-formamide at 0 - 20;
Stage #2: p-methoxybenzyl chloride in N,N-dimethyl-formamide; for 2 h;
Steps:
1.a.i
To a stirred solution of 4-iodo-lH-pyrazole (1.50 g, 7.73 mmol) in dry DMF (15 niL) at 00C was added sodium hydride (9.28 mmol, 60% dispersion in mineral oil) and the reaction mixture was allowed to warm to room temperature. After the evolution of hydrogen had ceased, 4-methoxy-benzyl chloride (1.06 mL, 7.80 mmol) was added and the reaction was stirred for 2 h and then quenched with water (50 mL) and extracted with diethyl ether (100 mL). The organic layer was washed with water (3 x 30 mL) and brine, dried over magnesium sulphate and the solvent removed under vacuum. The crude residue was washed with small portions of hexane and dried in vacuo, providing the product as a EPO
References:
WO2006/84338,2006,A1 Location in patent:Page/Page column 61-62
3469-69-0
387 suppliers
$5.00/1g
824-94-2
444 suppliers
$24.19/5G
905751-58-8
32 suppliers
$60.00/100mg
3469-69-0
387 suppliers
$5.00/1g
2746-25-0
173 suppliers
$27.57/250mgs:
905751-58-8
32 suppliers
$60.00/100mg