ChemicalBook CAS DataBase List 4-IODO-3-NITROTOLUENE

4-IODO-3-NITROTOLUENE synthesis

3synthesis methods

Product Name:4-IODO-3-NITROTOLUENE
CAS Number:5326-39-6
Molecular formula:C7H6INO2
Molecular Weight:263.03

27329-27-7 Synthesis

27329-27-7
101 suppliers
$7.00/250mg

5326-39-6
153 suppliers
$6.00/1g

Yield:5326-39-6 53%

Reaction Conditions:

with 2.9-dimethyl-1,10-phenanthroline;oxygen;copper (I) acetate;silver sulfate;sodium iodide in dimethyl sulfoxide at 160; for 24 h;Schlenk technique;

Steps:

18 Example 18. Synthesis of 2-nitro-4-methyl iodobenzene.
Silak reaction tube equipped with a magnetic stirrer was charged with 6.2 mg of silver sulfate,21.8 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline,36.2 mg of 2-nitro-4-methylbenzoic acid and 45 mg of sodium iodide4 mL of dimethyl sulfoxide. Heat 160 ° C in the presence of oxygenReaction for 24 hours. After the reaction was completed, distilled water was added to quench the reaction,Extraction with ethyl acetate 3 times, each time 10mL,The combined organic phases were concentrated to give 27.9 mg of 2-nitro-4-methyliodobenzene,The yield is 53%.

References:

Nanchang University;Fu Zhengjiang;Cai Hu;Li Zhaojie;Jiang Ligao CN107325002, 2017, A Location in patent:Paragraph 0091

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89-62-3 Synthesis