ChemicalBook CAS DataBase List 4-iodo-6-(trifluoromethyl)pyridin-3-amine

4-iodo-6-(trifluoromethyl)pyridin-3-amine synthesis

3synthesis methods

Product Name:4-iodo-6-(trifluoromethyl)pyridin-3-amine
CAS Number:1256810-65-7
Molecular formula:C6H4F3IN2
Molecular Weight:288.01

Carbamic acid, N-[4-iodo-6-(trifluoromethyl)-3-pyridinyl]-, 1,1-dimethylethyl ester

849353-40-8
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4-iodo-6-(trifluoromethyl)pyridin-3-amine

1256810-65-7
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Yield:1256810-65-7 91%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 21; for 24 h;

Steps:

11 4-iodo-6-(trifluoromethyl)pyridin-3-amine

4-iodo-6-(trifluoromethyl)pyridin-3-amine
Tert-butyl (4-iodo-6-(trifluoromethyl)pyridin-3-yl)carbamate (2.5 g, 6.44 mmol) was dissolved in dichloromethane (45 mL).
Trifluoroacetic acid (3.67 g, 32.2 mmol) was added to the solution.
The solution was stirred at 21° C. for 24 hours.
The solution was then taken up in excess dichloromethane and washed with saturated NaCl.
The organic layer was dried over MgSO₄ and concentrated down.
The crude product was purified by chromatography on silica gel (cyclohexane/ethyl acetate 80/20) and dried under vacuum. Yield: 91%. ¹H NMR (400 MHz, DMSO): 8.0 (s, 1H), 7.95 (s, 1H), 6.21 (s, 2H).
[M+1]⁺=289.0.

References:

US2017/239225,2017,A1 Location in patent:Paragraph 0145

106877-33-2
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1256810-65-7
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References

tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

325457-86-1
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1256810-65-7
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References