4-iodobenzenesulfonyl fluoride synthesis
- Product Name:4-iodobenzenesulfonyl fluoride
- CAS Number:4241-66-1
- Molecular formula:C6H4FIO2S
- Molecular Weight:286.06
98-61-3
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Yield:4241-66-1 96%
Reaction Conditions:
with potassium fluoride;18-crown-6 ether in acetonitrile at 20; for 18 h;
Steps:
58 Method 58; 4-Iodobenzenesulphonyl Fluoride
18-Crown-6 (0.5 g) and potassium fluoride (11.6 g, 200 mmol) were added to a solution of iodobenzenesulphonyl chloride (30.3 g, 100 mmol) in acetonitrile (100 ml) and the suspension was stirred for 18 hours at ambient temperature. The insolubles were removed by filtration and the solvent removed from the filtrate by evaporation. The residue was dissolved in EtOAc (300 ml), washed with water (2*150 ml), brine (100 ml), dried and the solvent evaporated to give the title compound (27.54 g, 96%) as a white solid. NMR 7.70 (d, 21H), 8.01 (d, 2H); m/z 286.
References:
US2004/14776,2004,A1 Location in patent:Page/Page column 35-36
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