![](/CAS/GIF/3058-39-7.gif)
4-Iodobenzonitrile synthesis
- Product Name:4-Iodobenzonitrile
- CAS Number:3058-39-7
- Molecular formula:C7H4IN
- Molecular Weight:229.02
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
707 suppliers
$10.00/50g
![4-Bromobenzonitrile](/CAS/GIF/623-00-7.gif)
623-00-7
468 suppliers
$6.00/10g
![4-Iodobenzonitrile](/CAS/GIF/3058-39-7.gif)
3058-39-7
283 suppliers
$10.00/1g
![Ethyl 4-iodobenzoate](/CAS/GIF/51934-41-9.gif)
51934-41-9
283 suppliers
$6.00/5g
Yield:3058-39-7 80% ,51934-41-9 15%
Reaction Conditions:
with copper(I) oxide;L-proline;potassium iodide at 110; for 30 h;Schlenk technique;Inert atmosphere;Sealed tube;
Steps:
2.2. General procedure for aryl and heteroaryl bromide-iodideexchange reaction
General procedure: A Schlenk tube was charged with Cu2O (7.2 mg, 10 mol%), l-proline (11.5 mg, 20 mol%), aryl (or heteroaryl) bromide (1 or 3,0.50 mmol), potassium iodide (KI) (249 mg, 0.75 mmol), and EtOH(1.5 mL) under nitrogen atmosphere. The Schlenk tube was sealedwith a teflon valve, and then the reaction mixture was stirred at110C for a period (the reaction progress was monitored by GCanalysis). After the reaction was completed, GC yield of high volatileproduct was determined using an appropriate internal standard(chlorobenzene or 1-chloro-4-methylbenzene) or the solvent wasremoved under reduced pressure. The residue obtained was puri-fied via silica gel chromatography (eluent: petroleum ether/ethylacetate = 10/1) to afford aryl iodides 2a-2o or heteroaryl iodides4a-4g.
References:
Feng, Xiujuan;Li, Lingyu;Yu, Xiaoqiang;Yamamoto, Yoshinori;Bao, Ming [Catalysis Today,2016,vol. 274,p. 129 - 132]
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873-74-5
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$9.00/1g
![4-Iodobenzonitrile](/CAS/GIF/3058-39-7.gif)
3058-39-7
283 suppliers
$10.00/1g
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126747-14-6
394 suppliers
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![4-Iodobenzonitrile](/CAS/GIF/3058-39-7.gif)
3058-39-7
283 suppliers
$10.00/1g
![4-Iodobenzyl alcohol](/CAS/GIF/18282-51-4.gif)
18282-51-4
207 suppliers
$10.00/1g
![4-Iodobenzonitrile](/CAS/GIF/3058-39-7.gif)
3058-39-7
283 suppliers
$10.00/1g
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624-31-7
424 suppliers
$9.00/25g
![4-Iodobenzonitrile](/CAS/GIF/3058-39-7.gif)
3058-39-7
283 suppliers
$10.00/1g