ChemicalBook CAS DataBase List 4-ISOPROPOXYBENZALDEHYDE

4-ISOPROPOXYBENZALDEHYDE synthesis

8synthesis methods

Product Name:4-ISOPROPOXYBENZALDEHYDE
CAS Number:18962-05-5
Molecular formula:C10H12O2
Molecular Weight:164.2

75-30-9
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$15.00/1g

123-08-0 Synthesis

123-08-0
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18962-05-5
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$6.00/1g

Yield:18962-05-5 77%

Reaction Conditions:

with potassium carbonate in hexane;ethyl acetate;N,N-dimethyl-formamide;

Steps:

R.3 4-Isopropoxybenzaldehyde

REFERENCE EXAMPLE 3 4-Isopropoxybenzaldehyde To a solution of 2 g (16.38 mmol) of 4-hydroxybenzaldehyde in 100 mL of DMF, 2.72 g (19.69 mmol) of K₂CO₃, 2.74 g (16.52 mmol) of KI and 3.94 mL (39.38 mmol) of 2-iodopropane was added under argon. The mixture was stirred at 80° C. overnight, concentrated and the residue obtained was partitioned between CHCl₃ and H₂O. The phases were separated, the aqueous phase was extracted with CHCl₃ and the combined organic phases were dried over MgSO₄ and concentrated. The crude product obtained was purified by chromatography on silica gel using EtOAc/hexane mixtures of increasing polarity as eluent, to give 2.08 g of the title compound of the example as an oil (77% yield). ¹H-NMR (300 MHz, CDCl₃ δ TMS): 1.39 (d, J=6 Hz, 6H), 4.67 (m, 1H), 6.96 (d, J=8.7 Hz, 2H), 7.81 (d, J=8.7 Hz, 2H), 9.87 (s, 1H).

References:

US2003/176481,2003,A1

123-08-0 Synthesis

123-08-0
901 suppliers
$5.00/10g