4-(METHANESULFINYL)BENZENEBORONIC ACID synthesis
- Product Name:4-(METHANESULFINYL)BENZENEBORONIC ACID
- CAS Number:166386-48-7
- Molecular formula:C7H9BO3S
- Molecular Weight:184.02
98546-51-1
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$5.00/1g
166386-48-7
68 suppliers
$84.90/100mg
14763-64-5
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1073-72-9
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Yield:-
Reaction Conditions:
with urea hydrogen peroxide adduct in methanol at 27 - 29;Green chemistry;chemoselective reaction;
Steps:
2.1 Solution phase protocol:
General procedure: To a stirred solution of aryl/alkyl boronic acid (1 mmol) in methanol or acetonitrile solvent (1 ml) was added 1 equiv. of Urea-Hydrogen peroxide (UHP) (2.5 equiv for alkyl boronic acids) at room temperature and the progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with dichloromethane (DCM). The combined organic layer was dried over anhydrous sodium sulfate (Na2SO4), evaporated and subjected to silica gel column chromatography for further purification.
References:
Gupta, Surabhi;Chaudhary, Priyanka;Srivastava, Vandana;Kandasamy, Jeyakumar [Tetrahedron Letters,2016,vol. 57,# 23,p. 2506 - 2510] Location in patent:supporting information
98546-51-1
269 suppliers
$5.00/1g
166386-48-7
68 suppliers
$84.90/100mg