4-Methanesulfonyl morpholine synthesis

8synthesis methods

Product Name:4-Methanesulfonyl morpholine
CAS Number:1697-34-3
Molecular formula:C5H11NO3S
Molecular Weight:165.21

13368-42-8
170 suppliers
$13.50/1G

124-63-0
6 suppliers
$10.00/5g

1697-34-3
21 suppliers
$65.00/50mg

Yield:1697-34-3 99%

Reaction Conditions:

in acetonitrile; for 1 h;Reflux;Inert atmosphere;

Steps:

Preparation of sulfonamide products

General procedure: The sulfonyl chloride (1mmol) is dissolved in 15 ml acetonitrile and then silylamine (1 mmol) is addedslowly. The reaction mixture is refluxed for 1 hour and concentrated withrotary evaporator. If necessary, the product may be further purified by silicagel chromatography (hexane: ethyl acetate).

References:

Naredla, Rajasekhar Reddy;Klumpp, Douglas A. [Tetrahedron Letters,2013,vol. 54,# 45,p. 5945 - 5947] Location in patent:supporting information

110-91-8 Synthesis