4-METHOXY-2'-METHYLTHIOBENZOPHENONE synthesis

Yield:760192-84-5 75%

Reaction Conditions:

Stage #1: 2-methylsulfanyl-benzoyl chloride;aluminum (III) chloride in dichloromethane at 0; for 0.0833333 h;
Stage #2: methoxybenzene in dichloromethane at 20; for 0.5 h;

Steps:

46

Example 46; (4-methoxyphenyl)(2-(methylthio)phenyl)methanone (C); To a mixture of 1.788 g 2-(methylthio)benzoyl chloride (B) (9.58 mmol) and1.6 g AICI₃ at 0°C was added slowly 20 ml DCM. The mixture was stirred 5 minutes at ambient temperature before 2 g anisole was added slowly. The reaction was stirred 30 minutes at ambient temperature and before water was added slowly. The mixture was extracted with DCM (2χ50ml). The combined organic extracts were washed with brine, dried over magnesium sulfate and concentrated. Flash silica chromatography (hexane:ethyl acetate 85:15) afforded 1.85 g pale yellow solid product (7.17 mmol, 75% yield).

References:

WO2008/13791,2008,A2 Location in patent:Page/Page column 50