4-Methoxy-2-trifluoromethyl-1H-benzoimidazole synthesis
- Product Name:4-Methoxy-2-trifluoromethyl-1H-benzoimidazole
- CAS Number:392-38-1
- Molecular formula:C9H7F3N2O
- Molecular Weight:216.16
Yield:392-38-1 94%
Reaction Conditions:
at 70; for 16 h;
Steps:
2. General Procedure A
General procedure: In a screw-cap vial, the diamine or aminothiophenol (1 mmol) was dissolved in fluorinated carboxylic acid (2 mL, 0.5 M) and the reaction was stirred at 70 °C for 16 hours. The fluorinated carboxylic acid was then evaporated under reduced pressure and the crude product was purified by silica gel column chromatography to yield the corresponding product.
References:
René, Olivier;Souverneva, Alexandra;Magnuson, Steven R.;Fauber, Benjamin P. [Tetrahedron Letters,2013,vol. 54,# 3,p. 201 - 204] Location in patent:supporting information
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