4-METHOXY-2-(TRIFLUOROMETHYL)BENZYL BROMIDE synthesis
- Product Name:4-METHOXY-2-(TRIFLUOROMETHYL)BENZYL BROMIDE
- CAS Number:916420-86-5
- Molecular formula:C9H8BrF3O
- Molecular Weight:269.06
773871-39-9
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916420-86-5
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Yield:916420-86-5 100%
Reaction Conditions:
with phosphorus tribromide in dichloromethane at 0 - 20; for 1.16667 h;
Steps:
21.A
A solution of (4-methoxy-2-trifluoromethyl-phenyl)-methanol (1.04 g, 5 mmol) in DCM (20 mL) was treated at 0° C. with phosphorous tribromide (1.64 g, 6 mmol). The reaction mixture was stirred for 10 minutes at 0° C., 1 h at room temperature. The solvent was evaporated in vacuo to yield a crude oil which was purified via flash chromatography (10% DCM in hexane) to yield the title compound as an oil (1.36 g, 100%)LC/MS: mass calcd. for C6H8BrF3O (m/z), 269.06; found, 270 [M+H]+.
References:
US2011/150864,2011,A1 Location in patent:Page/Page column 153
773871-39-9
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7789-60-8
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916420-86-5
14 suppliers
$104.00/1g