4-METHOXY-3-CHLOROPYRIDINE synthesis
- Product Name:4-METHOXY-3-CHLOROPYRIDINE
- CAS Number:89379-79-3
- Molecular formula:C6H6ClNO
- Molecular Weight:143.57
13194-60-0
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$27.00/250mg
124-41-4
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$12.00/25g
89379-79-3
47 suppliers
$10.00/100mg
Yield:89379-79-3 92%
Reaction Conditions:
in methanol at 20; for 2 h;
Steps:
1 Synthesis of 3-chloro-4-methoxypyridine
Into a 1000-mL round-bottom flask, was placed 3-chloro-4-nitropyridine (30.00 g, 189.2 mmol, 1.0 equiv), MeOH (400.0 mL), CILONa (56.7 mL, 5 mol/L, 1.50 equiv). The resulting solution was stirred for 2 hr at room temperature. The resulting mixture was concentrated under vacuum. The residue was dissolved in 500 mL of EA. The resulting mixture was washed with 3 x500 ml of brine. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 25 g (92.0%) of 3-chloro-4-methoxypyridine as yellow oil.
References:
WO2020/191091,2020,A1 Location in patent:Page/Page column 141-142
67-56-1
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89284-20-8
102 suppliers
$9.00/250mg
89379-79-3
47 suppliers
$10.00/100mg