4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL synthesis

13synthesis methods

Product Name:4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL
CAS Number:194873-98-8
Molecular formula:C14H11F3O
Molecular Weight:252.23

5720-07-0 Synthesis

5720-07-0
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$6.00/5g

98-15-7
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194873-98-8
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$437.00/1g

Yield:194873-98-8 96%

Reaction Conditions:

with potassium phosphate tribasic trihydrate;cis-[PdCl₂(Ph₂PNHpy)] in N,N-dimethyl-formamide at 100; for 15 h;Schlenk technique;Suzuki-Miyaura Coupling;

Steps:

1 4.4. General procedure for the Suzuki-Miyaura cross-coupling reaction of aryl chlorides with aryl boronic acids

General procedure: In a 25 mL Schlenk tube containing a magnetic stirrer bar, 4-chloroacetophenone (2a) (155 mg, 1 mmol) was mixed with 4-methoxyphenylboronic acid (3a) (228 mg, 1.5 mmol). Then trihydrate potassium phosphate (798 mg, 3 mmol) and DMF (5 mL) were added. The dissolved mixture of 1 (1.50 mL, 0.015 mmol) was transferred into the tube by a pipette. The tube was placed in a 100°C oil bath and stirred for 15 h. At the end of the reaction, the mixture was cooled to room temperature, added with water (5 mL), and then extracted with ethyl acetate (3×5 mL). The organic layer was dried over anhydrous Na₂SO₄. After evaporation of the solvent, the residue was subjected to silica gel column chromatography to give the cross-coupling product.

References:

Xu, Lin-Yan;Liu, Chun-Yu;Liu, Shi-Yuan;Ren, Zhi-Gang;Young, David James;Lang, Jian-Ping [Tetrahedron,2017,vol. 73,# 22,p. 3125 - 3132]