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1094396-87-8

4-Methoxy-D-tryptophan synthesis

2synthesis methods
-

Yield:1094396-87-8 79%

Reaction Conditions:

Stage #1: 4-methoxy-1H-indole;L-serinwith Salmonella enterica tryptophan synthase in methanol;aq. phosphate buffer at 37; pH=8.0;Enzymatic reaction;
Stage #2: with (2R)-aspartic acid in methanol;aq. phosphate buffer; pH=8.0;
Stage #3: in aq. phosphate buffer;deuteromethanol at 37; pH=8.0;Enzymatic reaction;stereoselective reaction;

References:

Parmeggiani, Fabio;Rué Casamajo, Arnau;Walton, Curtis J. W.;Galman, James L.;Turner, Nicholas J.;Chica, Roberto A. [ACS Catalysis,2019,vol. 9,# 4,p. 3482 - 3486]