4-Methoxy-N,6-dimethyl-1,3,5-triazin-2-amine synthesis
- Product Name:4-Methoxy-N,6-dimethyl-1,3,5-triazin-2-amine
- CAS Number:5248-39-5
- Molecular formula:C6H10N4O
- Molecular Weight:154.17
Yield:5248-39-5 96%
Reaction Conditions:
at 5 - 20; for 4 h;
Steps:
1.S3; 2.S3; 3.S3; 4.S3 Preparation of S3, 2-methyl-4-methoxy-6-methylamino-1,3,5-s-triazine (N-methyltriazine):
Add 238 grams of lower layer oil obtained in step S2 to a four-necked flask with stirring, and after cooling to 5°C,Then add 16 grams of monomethylamine and stir the reaction.After the reaction was kept for 2 hours, the temperature was raised to 20°C and the reaction was continued for 2 hours.After the reaction is over, 20 grams of water are added dropwise to dissolve a small amount of solids.After dissolution, two layers of oil and water are formed, and a total of 235 grams of oil is separated from the lower layer.Then the dichloromethane was removed under reduced pressure,After basic removal, add 80 grams of methanol for refining,After cooling to -5-0 and stirring for 1 hour,75 grams of N-methyltriazine obtained by filtration, content ≥99.0%,The yield is ≥96.0%.
References:
CN112694447, 2021, A Location in patent:Paragraph 0021; 0027; 0028; 0029; 0035; 0036; 0037; 0043
101200-48-0
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5248-39-5
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