ChemicalBook CAS DataBase List 4-METHOXY-N-METHYLBENZAMIDE

4-METHOXY-N-METHYLBENZAMIDE synthesis

8synthesis methods

Product Name:4-METHOXY-N-METHYLBENZAMIDE
CAS Number:3400-22-4
Molecular formula:C9H11NO2
Molecular Weight:165.19

104-93-8 Synthesis

104-93-8
382 suppliers
$6.00/25g

74-89-5 Synthesis

74-89-5
7 suppliers
$13.44/25ML

3400-22-4
44 suppliers
$16.00/100mg

Yield:3400-22-4 78%

Reaction Conditions:

with tert.-butylhydroperoxide;iron(III) chloride;tetra-(n-butyl)ammonium iodide in water at 60; for 24 h;Sealed tube;Molecular sieve;Green chemistry;

Steps:

9 Example 9

Add 4-methyl anisole (20 eq) to a clean 10 mL sealed tubeAnd methylamine 40% aqueous solution (0.24mmol),TBHP (70% water) 6 eq as oxidant,30 mol% TBAI and 15 mol% FeCl3 are used as catalysts,100 mg of 4A molecular sieve and 1.5 mL of water.React at 60 oC for 24 hours,TLC dot plate detection, after the reaction, the reaction solution is cooled to room temperature,The reaction solution was extracted with ethyl acetate (3×10 mL),Combine the organic phases and dry with anhydrous Na2SO4,The organic layer is concentrated and column chromatography to obtain pureN-methyl 4-methoxybenzamide, yellow solid, yield 78%.

References:

CN104761420,2021,B Location in patent:Paragraph 0015; 0049-0052

512-56-1 Synthesis