ChemicalBook CAS DataBase List 4-Methoxybicyclo<2.2.2>octane-1-carboxaldehyde

4-Methoxybicyclo<2.2.2>octane-1-carboxaldehyde synthesis

8synthesis methods

Product Name:4-Methoxybicyclo<2.2.2>octane-1-carboxaldehyde
CAS Number:94994-28-2
Molecular formula:C10H16O2
Molecular Weight:168.23

{4-methoxybicyclo[2.2.2]octan-1-yl}methanol

94994-19-1
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4-Methoxybicyclo<2.2.2>octane-1-carboxaldehyde

94994-28-2
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Yield:94994-28-2 52%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 20;

Steps:

55.7 Step 7. 4-Methoxybicyclo[2.2.2]octane-l-carbaldehyde (58h)

To a 1000 mL round-bottom flask was added [4-methoxybicyclo[2.2.2]octan-l- yljmethanol 58g (13 ,5 g, 79.30 mmol, 1 .0 equiv,), dichloromethane (600 mL), and Dess-Martin periodinate (51 g, 120.28 mmol, 1.5 equiv.). The resulting mixture was stirred overnight at RT and concentrated in vacuo. The residue was purified via silica gel column chromatography eluting with ethyl acetate/petroleum ether (5:95) to give 4-methoxybicyclo[2.2.2]octane-l- carbaldehyde 58h (7.0 g, 52%) as a white solid.

References:

WO2018/39384,2018,A1 Location in patent:Paragraph 00516

4-methoxybicyclo[2.2.2]octane-1-carboxylic acid

773-34-2
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$65.00/2.5mg

94994-28-2
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References

methyl 4-methoxybicyclo[2.2.2]octane-1-carboxylate

81687-90-3
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94994-28-2
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References

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

18720-35-9
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$19.00/1g

94994-28-2
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References

Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, 1-methyl ester, silver(1+) salt (1:1)

1403864-72-1
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94994-28-2
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References