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4-methyl-2-oxo-1,3-dioxane(WS203135) synthesis

10synthesis methods
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Yield:17361-58-9 85.5%

Reaction Conditions:

Stage #1: 1.3-butanediol;carbonic acid dimethyl esterwith Novozym435 at 60; for 7 h;Molecular sieve;Enzymatic reaction;
Stage #2: at 90; for 48 h;chemoselective reaction;

References:

Pyo, Sang-Hyun;Hatti-Kaul, Rajni [Advanced Synthesis and Catalysis,2012,vol. 354,# 5,p. 797 - 802] Location in patent:experimental part