ChemicalBook CAS DataBase List 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE

4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE synthesis

5synthesis methods

Product Name:4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE
CAS Number:55327-23-6
Molecular formula:C11H9NOS
Molecular Weight:203.26

61291-91-6 Synthesis

(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)METHANOL

61291-91-6
29 suppliers
$87.00/1g

4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE

55327-23-6
26 suppliers
$250.88/1g

Yield:55327-23-6 95%

Reaction Conditions:

with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide at 20;

Steps:

General Procedure for Synthesis of Aldehyde

General procedure: To a solution of (4-methyl-2-phenylthiazole-5-yl)methanol, 2a (10 mmol) in DMSO(30 mL), 2-iodoxybenzoic acid (11 mmol) was added, and the reaction mixture was stirredat 20 C. The progress of the reaction was monitored on TLC. After completion of thereaction (20 min), the reaction mixture was filtered and washed with DMSO (5 mL).Water(90 mL) was added to the filtrate and extracted with diethyl ether (3 × 30 mL). The organiclayer was washed with water, brine, and dried over sodium sulfate. The solvent was distilledto afford white solid 3a (1.93 g) in 95% yield.

References:

Shelke, Shivaji H.;Mhaske, Pravin C.;Hande, Pankaj;Bobade, Vivek D. [Phosphorus, Sulfur and Silicon and the Related Elements,2013,vol. 188,# 9,p. 1262 - 1270]

82294-70-0 Synthesis