4-(METHYL-PHENYL-AMINO)-BUTAN-2-ONE synthesis
- Product Name:4-(METHYL-PHENYL-AMINO)-BUTAN-2-ONE
- CAS Number:54493-25-3
- Molecular formula:C11H15NO
- Molecular Weight:177.24
Yield:54493-25-3 97%
Reaction Conditions:
with ionic liquid [bmim]BF4 stabilized magnetic cobalt nanoparticles in neat (no solvent) at 20; for 0.5 h;Michael Addition;
Steps:
3.2 General procedure for aza-Michael and thia-Michael additions
General procedure: 1mmol of amine or thiol and 1mmol of activated α,β-unsaturated compound (Michael acceptor) were stirred together in the presence of 5mol% (0.1mmol) of stabilized cobalt nanoparticles for an appropriate time (Scheme1). Following the completion of the reaction as indicated by TLC (hexane: ethyl acetate), dichloromethane was added to the reaction mixture and the cobalt catalyst was recovered by applying a magnetic field and decanting rest of the reaction mixture into another flask from where solvent was evaporated off and final product was isolated. Further purification was carried out by column chromatography on silica gel using ethyl acetate/petroleum ether as eluent. Structural assignments of the products were done based on their 1H NMR, 13C NMR and mass spectroscopic analysis.
References:
Dewan, Manika;De, Arnab;Mozumdar, Subho [Inorganic Chemistry Communications,2015,vol. 53,p. 92 - 96]
