4-methylbenzo[d]oxazol-2(3H)-one synthesis

12synthesis methods

Product Name:4-methylbenzo[d]oxazol-2(3H)-one
CAS Number:78258-80-7
Molecular formula:C8H7NO2
Molecular Weight:149.15

2835-97-4 Synthesis

2835-97-4
157 suppliers
$8.00/250mg

530-62-1 Synthesis

530-62-1
927 suppliers
$6.00/25g

78258-80-7
19 suppliers
$70.68/50mgs:

Yield:78258-80-7 99%

Reaction Conditions:

in acetonitrile at 23 - 70;

Steps:

80

To a solution of 2-amino-3-methylphenol (777 mg, 6.32 mmol) in acetonitrile (27 mL) at 23° C. was added 1,1'-carbonyldiimidazole (3.07 g, 18.9 mmol). The reaction mixture was heated to 70° C., and stirred overnight. The reaction mixture was cooled to room temperature and partitioned between ethyl acetate (150 mL) and H₂O (100 mL). The organic layer was separated and washed with brine (100 mL), dried (MgSO₄), and concentrated to yield the crude product, which was purified by silica gel column chromatography (20-50% EtOAc in hexanes) to yield 4-methyl-3H-benzooxazol-2-one (931 mg, 99%).

References:

US2006/211603,2006,A1 Location in patent:Page/Page column 68

201230-82-2 Synthesis