4-(Morpholin-4-ylmethyl)benzoic acid hydrochloride synthesis
- Product Name:4-(Morpholin-4-ylmethyl)benzoic acid hydrochloride
- CAS Number:65101-82-8
- Molecular formula:C12H16ClNO3
- Molecular Weight:257.7133
68453-56-5
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65101-82-8
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$65.00/500mg
Yield:-
Reaction Conditions:
with hydrogenchloride;water
Steps:
4.1.1.5. 4-Dimethylaminomethyl-benzoic acid hydrochloride (7)
General procedure: 4-Bromomethylbenzoate (6) (11.50 g, 50.2 mmol) was dropped to the mixture of amine (75.0 mmol), K2CO3 (17.25 g, 125.0 mmol), and KI (1.66 g, 10.0 mmol) in absolute ethanol (50 mL). The reaction was stirred overnight under an Argon atmosphere. The product was purified by extraction and hydrolyzed with 1.0 M HCl to give 4-dimethylaminomethyl-benzoic acid hydrochloride (7) as a pale white powder.
References:
Qiu, Jingying;Xu, Bixue;Huang, Zhengming;Pan, Weidong;Cao, Peixue;Liu, Changxiao;Hao, Xiaojiang;Song, Baoan;Liang, Guangyi [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 18,p. 5352 - 5360] Location in patent:experimental part
99-75-2
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65101-82-8
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$65.00/500mg
2417-72-3
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$7.00/5g
65101-82-8
15 suppliers
$65.00/500mg