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ChemicalBook CAS DataBase List 4-Morpholineethanol, α-methyl-, (αS)-

4-Morpholineethanol, α-methyl-, (αS)- synthesis

3synthesis methods
1-Propanone, 2-hydroxy-1-(4-morpholinyl)-, (2S)-

146432-17-9
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4-Morpholineethanol, α-methyl-, (αS)-

65617-17-6
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Yield:65617-17-6 67%

Reaction Conditions:

with borane*methyl sulfide;boron trifluoride diethyl etherate in 1,2-dimethoxyethane;Inert atmosphere;Reflux;

References:

Lewis, Frank W.;Eichler, Matthias C.;Grayson, David H. [Synlett,2009,# 12,p. 1923 - 1928] Location in patent:experimental part