4-(N-BOC-AMinophenyl)acetonitrile synthesis
- Product Name:4-(N-BOC-AMinophenyl)acetonitrile
- CAS Number:1233249-35-8
- Molecular formula:C13H16N2O2
- Molecular Weight:232.28
3544-25-0
289 suppliers
$10.00/5g
24424-99-5
826 suppliers
$13.50/25G
1233249-35-8
9 suppliers
inquiry
Yield:1233249-35-8 92%
Reaction Conditions:
in ethyl acetate at 25 - 30;
Steps:
3 Step 3 N-Boc-4-aminophenylacetonitrile (4)
Step 3 N-Boc-4-aminophenylacetonitrile (4) : To a solution of (208 gm, 1.57 moles) 4-aminophenylacetonitrile in 520ml of EtOAc, (429.8 gm, 1.96 moles) di-tert-butyl dicarbonate was added at 25-30°C over a period of 30-45 minutes. Reaction mixture was stirred at 25-30°C for 3-4 hrs. After completion of reaction as revealed from TLC, precipitated N-Boc-4- aminophenylacetonitnle (4) was filtered and washed with (2 X lOOvml) chilled ethanol. Solid after drying under vacuum at 50-60°C for 8-10 hrs weighed 333 gm. Dry weight: 333 gm (92%) 1H NMR (CDC13) and 400 MHz): δ 1.51(9H, s), 3.69 (2H, s), 6.55 (1H, s), 7.25 (2H, d), 7.37 (2H, d)
References:
WO2015/162536,2015,A1 Location in patent:Page/Page column 15-16
107-14-2
279 suppliers
$15.00/25g
380430-49-9
223 suppliers
$13.00/1g
1233249-35-8
9 suppliers
inquiry
555-21-5
43 suppliers
$21.00/25g
1233249-35-8
9 suppliers
inquiry
140-29-4
5 suppliers
$19.00/25mL
1233249-35-8
9 suppliers
inquiry