ChemicalBook CAS DataBase List 4-N-BUTOXYBENZYL BROMIDE

4-N-BUTOXYBENZYL BROMIDE synthesis

3synthesis methods

Product Name:4-N-BUTOXYBENZYL BROMIDE
CAS Number:2417-74-5
Molecular formula:C11H15BrO
Molecular Weight:243.14

The synthesis of 4-N-BUTOXYBENZYL BROMIDE is as follows:Under the protection of nitrogen,Add 40g of compound 5-1 to a 1L reaction flask,50g hydrogen bromide solution (hydrogen bromide concentration is 40wt%) and 500mL toluene,After fully dissolving, control the temperature between 110130,The reaction was stirred for 5h.Add 300 mL of ethyl acetate and 400 mL of water to the reaction solution for extraction,Collect the ethyl acetate layer, add anhydrous sodium sulfate for drying, then concentrate,Obtain 40 g of white solid (compound 6-1),The yield was 74.12%.
synthesis of 4-N-BUTOXYBENZYL BROMIDE.png

synthesis of 4-N-BUTOXYBENZYL BROMIDE.png

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Yield:2417-74-5 74.12%

Reaction Conditions:

with hydrogen bromide in toluene at 110 - 130; for 5 h;Inert atmosphere;

Steps:

5) Preparation of compound 6-1

Under the protection of nitrogen,Add 40g of compound 5-1 to a 1L reaction flask,50g hydrogen bromide solution (hydrogen bromide concentration is 40wt%) and 500mL toluene,After fully dissolving, control the temperature between 110130,The reaction was stirred for 5h.Add 300 mL of ethyl acetate and 400 mL of water to the reaction solution for extraction,Collect the ethyl acetate layer, add anhydrous sodium sulfate for drying, then concentrate,Obtain 40 g of white solid (compound 6-1),The yield was 74.12%.

References:

CN112940525,2021,A Location in patent:Paragraph 0084-0086

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References

10519-06-9 Synthesis

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References