4-OXOAZETIDINE-2-CARBOXYLIC ACID synthesis
- Product Name:4-OXOAZETIDINE-2-CARBOXYLIC ACID
- CAS Number:98019-65-9
- Molecular formula:C4H5NO3
- Molecular Weight:115.09
95729-87-6
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Yield:-
Reaction Conditions:
in methanol;palladium-carbon
Steps:
R.14 REFERENCE EXAMPLE 14 STR56
REFERENCE EXAMPLE 14 STR56 In 250 ml of methanol was dissolved 5 g of compound (43) and the compound was catalytically reduced in the presence of 500 mg of palladium-carbon at normal temperature and normal pressure in a hdyrogen atmosphere. After filtering off the catalyst, methanol was distilled off under reduced pressure. The residue thus formed was crystallized from ether and the crystals thus formed were collected by filtration to provide 2.5 g of the desired product, (R)-2-azetidinone-4-carboxylic acid (44) as the colorless crystals. M. p. 97°-101° C. NMR (DMSO-d6, CD3 OD) δppm: 4.60 (1H, d,d, 4-position hydrogen), 3.23 (1H, d,d, 3-position hydrogen), 2.85 (1H, d,d, 3-position hydrogen) IR (KBr) cm-1: 3310, 1735 (broad), 860
References:
Yamanouchi Pharmaceutical Co., Ltd. US4564609, 1986, A