Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

4-piperazin-1-ylquinazoline synthesis

6synthesis methods
-

Yield:59215-41-7 84%

Reaction Conditions:

with hydrogenchloride in water;ethyl acetate at 20; for 6 h;

Steps:

1.6 6) Preparation of intermediate K-3

Weigh the intermediate K-2 (3.0 g, 9.54 mmol),Dissolved in ethyl acetate (6 mL) at room temperatureAdd (2 mL) concentrated hydrochloric acid and stir at room temperature for 6 h.An off-white solid was isolated, which was filtered and dried to give pale white intermediate K-3 (2.3 g).

References:

CN108358936,2018,A Location in patent:Paragraph 0094; 0108-0110