4-PIPERAZIN-1-YLTHIENO[3,2-C]PYRIDINE synthesis
- Product Name:4-PIPERAZIN-1-YLTHIENO[3,2-C]PYRIDINE
- CAS Number:106261-27-2
- Molecular formula:C11H13N3S
- Molecular Weight:219.31
110-85-0
550 suppliers
$5.00/5G
![4-Chlorothieno[3,2-c]pyridine](/CAS/GIF/27685-94-5.gif)
27685-94-5
110 suppliers
$32.60/250mg
106261-27-2
20 suppliers
$200.00/50mg
Yield:106261-27-2 74%
Reaction Conditions:
Stage #1: piperazine;4-chlorothieno[3,2-c]pyridine for 5 h;Reflux;Industry scale;
Stage #2: with hydrogenchloride in water;Industry scale;
Stage #3: with sodium hydroxide in water;Industry scale;
Steps:
1.1.1
1 kg of 4-chlorothieno[3,2-c]pyridine (1 eq.), 1.5 kg of piperazine (3 eq.) and 8 l of 1-pentanol or of isoamyl alcohol are introduced into a reactor. The mixture is refluxed for 5 h and cooled, and the piperazine hydrochloride formed is filtered. 2.4 l of water are added to the filtrate and the mixture is acidified with concentrated hydrochloric acid. After separation by settling out, the aqueous phase is brought to a basic pH with a solution of 2.3 l of 30% sodium hydroxide and 2.6 l of water, and then extracted with two times 1.3 l of toluene. The toluenic phase is concentrated by half and 3.5 l of methylcyclohexane are added. The mixture is cooled to 0° C. and filtered and the product obtained is dried under vacuum at 50° C. A pale yellow powder of compound (IV) is obtained.Yield: 74%Analyses: HPLC=99.2%
References:
US2010/94005,2010,A1 Location in patent:Page/Page column 2
110-85-0
550 suppliers
$5.00/5G
27685-94-5
110 suppliers
$32.60/250mg
123-51-3
522 suppliers
$29.00/25mL
71-41-0
428 suppliers
$10.00/25mL
106261-27-2
20 suppliers
$200.00/50mg
![4-HYDROXYTHIENO[3,2-C]PYRIDINE](/CAS/GIF/27685-92-3.gif)
27685-92-3
81 suppliers
$74.00/100mg
106261-27-2
20 suppliers
$200.00/50mg