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ChemicalBook CAS DataBase List [4-(PIPERIDIN-1-YLMETHYL)PHENYL]METHANOL

[4-(PIPERIDIN-1-YLMETHYL)PHENYL]METHANOL synthesis

6synthesis methods
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Yield:91271-62-4 95%

Reaction Conditions:

Stage #1: 1-((4-formylphenyl)carbonyl)piperidinewith phenylsilane;caesium carbonate in 2-methyltetrahydrofuran at 60; for 6 h;Green chemistry;
Stage #2: with ethanol in 2-methyltetrahydrofuran at 80; for 2 h;Green chemistry;chemoselective reaction;

References:

Li, Hu;Zhao, Wenfeng;Dai, Wenshuai;Long, Jingxuan;Watanabe, Masaru;Meier, Sebastian;Saravanamurugan, Shunmugavel;Yang, Song;Riisager, Anders [Green Chemistry,2018,vol. 20,# 23,p. 5327 - 5335]

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