![](/CAS/20150408/GIF/586375-35-1.gif)
4-Piperidinol, 4-methyl-, hydrochloride (1:1) synthesis
- Product Name:4-Piperidinol, 4-methyl-, hydrochloride (1:1)
- CAS Number:586375-35-1
- Molecular formula:C6H14ClNO
- Molecular Weight:151.6345
![N-BOC-4-METHYL-4-HYDROXY PIPERIDINE](/CAS/GIF/406235-30-1.gif)
406235-30-1
117 suppliers
$22.00/250mg
![4-Piperidinol, 4-methyl-, hydrochloride (1:1)](/CAS/20150408/GIF/586375-35-1.gif)
586375-35-1
93 suppliers
$24.75/0.5g
Yield: 100%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;methanol at 0 - 20; for 4 h;
Steps:
4-Methylpiperidin-4-ol hydrochloride:
To solution of tert-butyl 4-hydroxy-4-methylpiperidine- 1 -carboxylate (5 g, 23.2 mmol) inMeOH (5 mL) was added 4.0 M HC1 in 1,4-Dioxane (17 mL) at 0 °C. The reaction mixturewas stirred at room temperature for 4 h. After completion, the volatiles were concentrated under reduced pressure to afford 3 g of 4-methylpiperidin-4-ol hydrochloride (Quantitative).
References:
THE BROAD INSTITUTE, INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;HOLSON, Edward;WAGNER, Florence, Fevrier;WEIWER, Michel;SCOLNICK, Edward;PALMER, Michelle;DORDEVIC, Luka;LEWIS, Michael;PAN, Jennifer, Q.;ZHANG, Yan-Ling;XU, Qihong WO2016/100940, 2016, A1 Location in patent:Page/Page column 161
![1-BENZYL-4-METHYLPIPERIDIN-4-OL](/CAS/GIF/3970-66-9.gif)
3970-66-9
44 suppliers
$65.00/50mg
![4-Piperidinol, 4-methyl-, hydrochloride (1:1)](/CAS/20150408/GIF/586375-35-1.gif)
586375-35-1
93 suppliers
$24.75/0.5g
![4-Hydroxy-4-methylpiperidine-1-carboxylic acid benzyl ester](/CAS/GIF/169750-57-6.gif)
169750-57-6
39 suppliers
$145.00/1g
![4-Piperidinol, 4-methyl-, hydrochloride (1:1)](/CAS/20150408/GIF/586375-35-1.gif)
586375-35-1
93 suppliers
$24.75/0.5g
![4-METHYLPIPERIDIN-4-OL](/CAS/GIF/3970-68-1.gif)
3970-68-1
116 suppliers
$45.00/250mg
![4-Piperidinol, 4-methyl-, hydrochloride (1:1)](/CAS/20150408/GIF/586375-35-1.gif)
586375-35-1
93 suppliers
$24.75/0.5g
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
264 suppliers
$12.00/10ml
![N-(tert-Butoxycarbonyl)-4-piperidone](/CAS/GIF/79099-07-3.gif)
79099-07-3
543 suppliers
$5.00/5g
![4-Piperidinol, 4-methyl-, hydrochloride (1:1)](/CAS/20150408/GIF/586375-35-1.gif)
586375-35-1
93 suppliers
$24.75/0.5g