4-Pyridinecarboxamide,N-cyclopropyl-(9CI) synthesis

1synthesis methods

Product Name:4-Pyridinecarboxamide,N-cyclopropyl-(9CI)
CAS Number:25764-75-4
Molecular formula:C9H10N2O
Molecular Weight:162.19

1570-45-2 Synthesis

1570-45-2
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$7.00/10g

765-30-0
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$10.00/25g

4-Pyridinecarboxamide,N-cyclopropyl-(9CI)

25764-75-4
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$131.59/100mg

Yield:25764-75-4 50%

Reaction Conditions:

at 120; for 40 h;

Steps:

787.1 Example 787; 4-(5-{2-[3-(3-CHLORO-PHENYL)-[1,2,4]OXADIAZOL-5-YL]-PROPYL}-4-CYCLOPROPYL-4H-[1,2,4]triazol-3-yl)-pyridine; Step 1: N-Cyclopropyl-isonicotinamide:

Isonicotinic acid ethyl ester (3.0 g, 20 mmol) was mixed with cyclopropylamine (2 ml) at [120 °C] in a sealed vial for 40 h. The reaction mixture was triturated with ether to give 1.62 g (50 %) of N-cyclopropyl-isonicotinamide as off-white solid. [1H-NMR] [(CDC13)] d (ppm): 8. 73 (d, 2H), 7.60 (d, 2H) and 6.55 (w, 1H), 2.92 (m, 1H), 0.90 (m, 2H) and 0.66 (m, 2H).

References:

WO2004/14881,2004,A2 Location in patent:Page 259