4-Pyridinol,2-methoxy-(6CI,9CI) synthesis
- Product Name:4-Pyridinol,2-methoxy-(6CI,9CI)
- CAS Number:66080-45-3
- Molecular formula:C6H7NO2
- Molecular Weight:125.13
66080-44-2
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66080-45-3
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Yield: 99%
Reaction Conditions:
with hydrogen;5%-palladium/activated carbon in ethanol at 20; for 2 h;
Steps:
16.16.b
(16b) 2-Methoxypyridin-4-ol A solution of 4-(benzyloxy)-2-methoxypyridine produced in Example (16a) (4.65 g, 21.6 mmol) and 10% palladium carbon (2.30 g, 2.16 mmol) in ethanol (100 mL) was stirred in a hydrogen atmosphere at room temperature for 30 minutes. The insoluble matter was separated by filtration and then the filtrate was concentrated to obtain the title compound (2.70 g, 99%) as a colorless oil. 1H-NMR (400 MHz, CDCl3): δ ppm: 3.90 (3H, s), 6.13 (1H, s), 6.42 (1H, d, J = 5.9 Hz), 7.80 (1H, brs).
References:
Daiichi Sankyo Company, Limited EP2404918, 2012, A1 Location in patent:Page/Page column 34
53937-02-3
164 suppliers
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66080-45-3
97 suppliers
$20.00/1g
53937-02-3
164 suppliers
$60.00/5 g
66080-45-3
97 suppliers
$20.00/1g