4-Pyrimidinamine, 2-cyclopropyl- (9CI) synthesis
- Product Name:4-Pyrimidinamine, 2-cyclopropyl- (9CI)
- CAS Number:265324-26-3
- Molecular formula:C7H9N3
- Molecular Weight:135.17
61310-53-0
139 suppliers
$45.00/100mg
57297-29-7
203 suppliers
$8.00/1g
265324-26-3
38 suppliers
$193.91/250mg
Yield:265324-26-3 85%
Reaction Conditions:
Stage #1: cyclopropylcarboxamidine hydrochloridewith sodium methylate in methanol at 20; for 0.5 h;
Stage #2: 3-ethoxyacrylonitrile at 135; for 3 h;
Steps:
1 2-Cyclopropylpyrimidin-4-amine
2-Cyclopropylpyrimidin-4-amine
A suspension of cyclopropylcarbamidine hydrochloride (1.0 g, 8.3 mmol) in sodium methoxide (0.5 M in MeOH, 16.6 mL, 8.3 mmol) was allowed to stir at rt for 30 min.
The mixture was then filtered and concentrated.
Ethoxyacrylonitrile (0.85 mL, 8.3 mmol) was added and the reaction was allowed to stir at 135° C. for 3 h, then allowed to cool to rt and stir for another 16 h.
The reaction was concentrated and the crude product was purified by column chromatography to provide 2-cyclopropylpyrimidin-4-amine (1.10 g, 85.0%) as a solid. LCMS (FA): m/z=136.2 (M+H).
References:
US2015/225422,2015,A1 Location in patent:Paragraph 0264-0265
57297-29-7
203 suppliers
$8.00/1g
920-37-6
309 suppliers
$10.60/1gm:
265324-26-3
38 suppliers
$193.91/250mg
61310-53-0
139 suppliers
$45.00/100mg
265324-26-3
38 suppliers
$193.91/250mg
7043-09-6
62 suppliers
$26.00/250mg
265324-26-3
38 suppliers
$193.91/250mg