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4-QUINOLINECARBOXYLIC ACID,7-CHLORO-2-PHENYL- synthesis

6synthesis methods
-

Yield:5439-80-5 95%

Reaction Conditions:

Stage #1: benzaldehyde;2-oxo-propionic acid for 0.00833333 h;Closed vessel;Microwave irradiation;Doebner reaction;
Stage #2: 3-chloro-aniline for 0.00833333 h;Microwave irradiation;

References:

Bhatt, Hardik G.;Agrawal, Yadvendra K. [Medicinal Chemistry Research,2010,vol. 19,# 4,p. 392 - 402] Location in patent:experimental part

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