4-T-BUTYL-6-HYDROXYPYRIMIDINE synthesis
- Product Name:4-T-BUTYL-6-HYDROXYPYRIMIDINE
- CAS Number:3438-49-1
- Molecular formula:C8H12N2O
- Molecular Weight:152.19
66698-66-6
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$45.00/50mg
3438-49-1
15 suppliers
$200.00/100mg
Yield:3438-49-1 96%
Reaction Conditions:
with nickel in ethanol; for 3 h;
Steps:
281
Procedure adapted from: J. Med. Chem. 2002,45, 1918-1929. 6-tert-Butyl- 2-mercapto-pyrimidin-4-ol (1.0 g, 5.4 mmol), synthesized according to the procedure described in J. Am. Chem. Soc. 1945,67, 2197, was dissolved in boiling EtOH (30 mL). Raney Ni 2800 slurry (Aldrich) was added to the mixture dropwise until starting material had been determined by TLC to be completely consumed (approx. 5 mL of slurry over 3 h). The mixture was filtered through diatomaceous earth, washed with EtOH (50 mL). The filtrate was concentrated under reduced pressure to give 794 mg, 96% of desired product: Rf = 0.13 (1: 1 EtOAc/hexanes); 1H NMR (300 MHz, MeOD-d4) 68. 14 (s, 1H), 6.37 (s, 1H), 1.29 (s, 9H).
References:
WO2005/87751,2005,A2 Location in patent:Page/Page column 171; 172
55107-14-7
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$10.00/1g
3473-63-0
482 suppliers
$5.00/25g
3438-49-1
15 suppliers
$200.00/100mg