4-TERT-BUTYL-1,2-DIMETHOXYBENZENE synthesis
- Product Name:4-TERT-BUTYL-1,2-DIMETHOXYBENZENE
- CAS Number:41280-64-2
- Molecular formula:C12H18O2
- Molecular Weight:194.27
Yield:41280-64-2 70%
Reaction Conditions:
with silica gel supported sodium hydrogen sulfate in 1,2-dichloro-ethane at 80; for 8 h;Friedel-Crafts type alkylation;
Steps:
Typical procedure: A mixture of 1 (2.0 mmol), 2 (3.0 mmol) and NaHSO4/SiO2 (2.1 mmol/g, 1.00 g) in DCE (5 mL)was stirred at 30 °C for 0.5 h, and then the used supported reagent was removed by filtration. The filtrate wasevaporated to leave crude product, which was purified by column chromatography (hexane/ethyl acetate) to obtain 3.
References:
Sato, Yuta;Aoyama, Tadashi;Takido, Toshio;Kodomari, Mitsuo [Tetrahedron,2012,vol. 68,# 35,p. 7077 - 7081] Location in patent:supporting information; experimental part
90-05-1
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