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87015-91-6

(4-TERT-BUTYL-BENZOYLAMINO)-ACETIC ACID synthesis

2synthesis methods
-

Yield:87015-91-6 30%

Reaction Conditions:

Stage #1: glycinewith sodium hydroxide in water at 20;
Stage #2: p-tert-butyl benzoyl chloride in water at 60;

Steps:

4 Example 4; N-[(4-TERT-BUTYL) BENZOYLZ GLYCINE.

Glycine (0.78 g, 1.0 mmol) was dissolved in 1.0 N aqueous NAOH (10 mL) at room temperature. 4-tert-Butylbenzoyl chloride was added, and the biphasic mixture was heated to 60 C and vigorously stirred overnight. A heavy white precipitate gradually formed ; it was collected by suction filtration and washed with ether to remove 4-tert- butybenzoic acid. The product, a white powder, weighed 0. 70 g (30%) and was used without further purification.

References:

WO2004/50613,2004,A2 Location in patent:Page 57