4-Thiazolecarboxylic acid tert-butyl ester synthesis
1synthesis methods
- Product Name:4-Thiazolecarboxylic acid tert-butyl ester
- CAS Number:1037746-91-0
- Molecular formula:C8H11NO2S
- Molecular Weight:185.24
Yield:1037746-91-0 94%
Reaction Conditions:
Stage #1: Thiazole-4-carboxylic acidwith 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide at 50; for 1 h;Inert atmosphere;
Stage #2: tert-butyl alcoholwith 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide at 60; for 48 h;Inert atmosphere;
References:
Hédouin, Jonathan;Schneider, Cédric;Gillaizeau, Isabelle;Hoarau, Christophe [Organic Letters,2018,vol. 20,# 19,p. 6027 - 6032] Location in patent:supporting information