4-Thiazolemethanamine, 2-amino-N,N-dimethyl- synthesis
- Product Name:4-Thiazolemethanamine, 2-amino-N,N-dimethyl-
- CAS Number:116252-53-0
- Molecular formula:C6H11N3S
- Molecular Weight:157.24
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Yield:116252-53-0 53%
Reaction Conditions:
in water at 0; for 1 h;
Steps:
284 Reference Example 284; 4-[(dimethylamino) methyl]-1, 3-thiazole-2-amine
4- (CHLOROMETHYL)-1, 3-thiazole-2-amine hydrochloride (8.2 g, 37 mmol) was dissolved in water (5 mL), and an aqueous solution of 50% dimethylamine (50 mL) was added dropwise under ice-cooling. The mixture was stirred for 1 hr. and water was poured into the reaction solution. The mixture was extracted with ethyl acetate, and the extract was washed with saturated brine, dried (MGSO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound as white crystals (3.05 g, yield 53%). 1H NMR (300 MHz, CDC13) 8 ppm: 2.26 (s, 6 H), 3.31 (s, 2 H), 4.91 (br, 2 H), 6.30 (s, 1 H)
References:
WO2004/46107,2004,A1 Location in patent:Page 220-221
