![](/CAS/GIF/937663-77-9.gif)
4-Thiazolemethanol, 2-ethyl- synthesis
- Product Name:4-Thiazolemethanol, 2-ethyl-
- CAS Number:937663-77-9
- Molecular formula:C6H9NOS
- Molecular Weight:143.21
![4-Thiazolecarboxylicacid,2-ethyl-,ethylester(9CI)](/CAS/GIF/76706-67-7.gif)
76706-67-7
17 suppliers
$252.00/500mg
![4-Thiazolemethanol, 2-ethyl-](/CAS/GIF/937663-77-9.gif)
937663-77-9
11 suppliers
$45.00/50mg
Yield:937663-77-9 65%
Reaction Conditions:
with methanol;sodium tetrahydridoborate at 20;
Steps:
XXX.1 Step 1 : (2-Ethylthiazol-4-yl)methanol
Step 1 : (2-Ethylthiazol-4-yl)methanol To a solution of ethyl 2-ethylthiazole-4-carboxylate (1 g, 5.4 mmol) in CH3OH (20ml) was added NaBH4 (2.04 g, 54 mmol) by portion. The resulting mixture was stirred at room temperature. After TLC analysis showed the starting material was disappeared. The solvent was removed in vacuo. The residue was dissolved in DCM (50 mL) and washed with H20. The organic layer was dried and concentrated to give (2-ethylthiazol-4-yl) methanol (0.5 g, 65%): 1H NMR (400 MHz, CD3OD) δ 7.23-7.22 (m, 1H), 4.64 (m, 2H), 3.03-2.98 (m, 3H), 1.35 (t, J = 7.6 Hz, 2H).
References:
WO2013/149362,2013,A1 Location in patent:Page/Page column 52