![](/CAS/GIF/128238-43-7.gif)
4-(TRIFLUOROACETYLAMINO)-1-BUTANOL synthesis
- Product Name:4-(TRIFLUOROACETYLAMINO)-1-BUTANOL
- CAS Number:128238-43-7
- Molecular formula:C6H10F3NO2
- Molecular Weight:185.14
![4-Amino-1-butanol](/CAS/GIF/13325-10-5.gif)
13325-10-5
307 suppliers
$10.00/1g
![Ethyl trifluoroacetate](/CAS/GIF/383-63-1.gif)
383-63-1
475 suppliers
$10.00/25g
![4-(TRIFLUOROACETYLAMINO)-1-BUTANOL](/CAS/GIF/128238-43-7.gif)
128238-43-7
12 suppliers
$97.09/1ml
Yield:128238-43-7 100%
Reaction Conditions:
in ethanol at 20;
Steps:
(1) 4-trifluoroacetamidobutanol (Compound 11)
(1)
4-trifluoroacetamidobutanol (Compound 11)
A solution (100 ml) of 4-aminobutanol (2.50 g, 28.05 mmol) and trifluoroacetic acid ethyl ester (19.92 g, 140.26 mmol) in ethanol was stirred at room temperature overnight.
The reaction mixture was concentrated under reduced pressure to give 4-trifluoroacetamidobutanol (11) (5.44 g, q.) as a colorless syrup.
References:
US9404108,2016,B2 Location in patent:Page/Page column 30; 34
![4-Amino-1-butanol](/CAS/GIF/13325-10-5.gif)
13325-10-5
307 suppliers
$10.00/1g
![Trifluoroacetic anhydride](/CAS/GIF/407-25-0.gif)
407-25-0
436 suppliers
$9.00/1g
![4-(TRIFLUOROACETYLAMINO)-1-BUTANOL](/CAS/GIF/128238-43-7.gif)
128238-43-7
12 suppliers
$97.09/1ml
![4-Amino-1-butanol](/CAS/GIF/13325-10-5.gif)
13325-10-5
307 suppliers
$10.00/1g
![Methyl trifluoroacetate](/CAS/GIF/431-47-0.gif)
431-47-0
277 suppliers
$10.00/5g
![4-(TRIFLUOROACETYLAMINO)-1-BUTANOL](/CAS/GIF/128238-43-7.gif)
128238-43-7
12 suppliers
$97.09/1ml