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ChemicalBook CAS DataBase List 4-(Trifluoromethoxy)chlorobenzene
461-81-4

4-(Trifluoromethoxy)chlorobenzene synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere
2: sodium hydroxide / methanol; tetrahydrofuran; water / 23 °C / Inert atmosphere
3: xenon difluoride / chloroform-d1 / 0.08 h / 23 °C / Inert atmosphere; Sealed tube

References:

Chatalova-Sazepin, Claire;Binayeva, Meruyert;Epifanov, Maxim;Zhang, Wei;Foth, Paul;Amador, Carolyn;Jagdeo, Manu;Boswell, Benjamin R.;Sammis, Glenn M. [Organic Letters,2016,vol. 18,# 18,p. 4570 - 4573]

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