4-(Trifluoromethyl)phenacyl bromide synthesis
- Product Name:4-(Trifluoromethyl)phenacyl bromide
- CAS Number:383-53-9
- Molecular formula:C9H6BrF3O
- Molecular Weight:267.04
709-63-7
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383-53-9
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Yield:383-53-9 87%
Reaction Conditions:
with N-Bromosuccinimide in ethyl acetate at 40;
Steps:
42.1 42.1 Preparation of α-Bromo-4-trifluoromethylacetophenone
10 mmol 4-trifluoromethyl acetophenone is added to a 100 mL round bottom flaskAnd 11mmol of N-bromosuccinimide (NBS),35mL of ethyl acetate dissolved,Then add 1g of Amberlyst 15 ion exchange resin as catalyst.The reaction solution was warmed to 40°C to react. After TLC tracks the reaction,The reaction solution was filtered to remove Amberlyst 15 ion exchange resin,The filtrate was evaporated to dryness and column chromatography (eluent: petroleum ether/dichloromethane) gave white crystals.Yield 87%.
References:
Shanghai Pharmaceutical Industry Institute;East China University of Science and Technology;Chen Daijie;Xu Xiaoyong;Shao Lei;Li Zhong;Dong Xiaojing;Hou Shuang;Zhang Junliang;Wang Rong CN107629022, 2018, A Location in patent:Paragraph 0473; 0474; 0475; 0476
313343-88-3
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383-53-9
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705-31-7
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383-53-9
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402-50-6
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383-53-9
134 suppliers
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